Team:Montgomery Cougars NJUSA/Project/PathogenesisofAcne

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(Pathogenesis of Acne)
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==Pathogenesis of Acne==
==Pathogenesis of Acne==
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Acne Vulgaris occurs due to several factors. Comedogenesis is the obstruction of sebaceous follicles due to greater cohesiveness of the follicular epithelial cells. Another factor, excessive sebum production is caused by androgenic stimulation of sebaceous glands. A third factor is the number of ''Propionibacterium acnes''. ''P acnes'' produces substances which exacerbate inflammation. Inflammation as a result of ''P Acnes'' proliferation can extend into the dermis and result in paules, pustules, and arid nodules.  
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Acne Vulgaris results due to blocked follicles. Comedogenesis is the obstruction of sebaceous follicles due to greater cohesiveness of the follicular epithelial cells and sebum. In this environment, the bacteria ''Propionibacterium acnes'' proliferates and causes inflammation, and consequently inflammatory papules, pustules, and nodulocystic lesions. Another factor, excessive sebum production is caused by androgenic stimulation of sebaceous glands.
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=The Role of Sebum=
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An increase in sebum is a direct result of increased production of adrenal and gonadal androgens (which occurs during the onset of puberty).  
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Revision as of 19:00, 30 May 2014

Pathogenesis of Acne

Acne Vulgaris results due to blocked follicles. Comedogenesis is the obstruction of sebaceous follicles due to greater cohesiveness of the follicular epithelial cells and sebum. In this environment, the bacteria Propionibacterium acnes proliferates and causes inflammation, and consequently inflammatory papules, pustules, and nodulocystic lesions. Another factor, excessive sebum production is caused by androgenic stimulation of sebaceous glands.


The Role of Sebum

An increase in sebum is a direct result of increased production of adrenal and gonadal androgens (which occurs during the onset of puberty).


Our Project

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