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| #col_left{ | | #col_left{ |
- | float: left; | + | float: center; |
| width: 576px; | | width: 576px; |
| padding: 30px 0px; | | padding: 30px 0px; |
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| } | | } |
| #col_right{ | | #col_right{ |
- | float: right; | + | float: center; |
| width: 242px; | | width: 242px; |
| padding: 30px 28px 30px 15px; | | padding: 30px 28px 30px 15px; |
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| } | | } |
| #col_nav{ | | #col_nav{ |
- | float: left; | + | float: center; |
| width: 200px; | | width: 200px; |
| padding: 30px 15px 30px 50px; | | padding: 30px 15px 30px 50px; |
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| #top-section, #top-section * { border: none !important; border: none;} | | #top-section, #top-section * { border: none !important; border: none;} |
- | #footer-box { left: -5px } | + | #footer-box style="width: 953px;" |
| #accordion h3 { margin-bottom: 1px; } | | #accordion h3 { margin-bottom: 1px; } |
| #catlinks { display: none;} | | #catlinks { display: none;} |
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| .nav{ | | .nav{ |
| float:left; | | float:left; |
- | width:100%; | + | width:1000px; |
| margin:0; | | margin:0; |
| list-style:none; | | list-style:none; |
| position:relative; | | position:relative; |
| + | |
| z-index:5; | | z-index:5; |
- | /*CHANGE THIS TO CENTER*/
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| padding:0 12px; /*12px;*/ | | padding:0 12px; /*12px;*/ |
| } | | } |
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| <body> | | <body> |
- | <div id="project_header" style="margin-top: -2.3em; position:relative;"> | + | <div id="project_header" style="margin-top: -0em; position:relative;"> |
| <a href="http://2014HS.igem.org/Team:HUNGENIOUS"> | | <a href="http://2014HS.igem.org/Team:HUNGENIOUS"> |
- | <img src="https://static.igem.org/mediawiki/2014hs/6/6e/HUNGENIOUS_logo.png"> | + | <img src="https://static.igem.org/mediawiki/2014hs/6/6e/HUNGENIOUS_logo.png" style="width:1000px;"> |
| </a> | | </a> |
| </div> | | </div> |
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- | <div style="float:left; clear:left; margin-top: -2.5em; z-index:1; position:relative;"> | + | |
| <a href="https://2014hs.igem.org"> | | <a href="https://2014hs.igem.org"> |
| <img src="https://static.igem.org/mediawiki/2012/7/79/IGEM-100px.png" alt="iGEM 2012"> | | <img src="https://static.igem.org/mediawiki/2012/7/79/IGEM-100px.png" alt="iGEM 2012"> |
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- | <div id="project_title" style="text-align: center; margin-top: -0.8em; float:left; z-index:1; position:relative; | + | <div id="project_title" style="text-align: center; margin-top: -0.8em; float: center; z-index:1; position:relative; |
| margin-left:3em;"> | | margin-left:3em;"> |
| <a href="https://2014hs.igem.org/Team:HUNGENIOUS"> | | <a href="https://2014hs.igem.org/Team:HUNGENIOUS"> |
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| Treatment of Crohn's Disease by Probiotic E.coli Bacteria | | Treatment of Crohn's Disease by Probiotic E.coli Bacteria |
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| + | |
| </h1> | | </h1> |
| </a> | | </a> |
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| <li><a href="https://2014hs.igem.org/Team:HUNGENIOUS/Summary">Summary</a></li> | | <li><a href="https://2014hs.igem.org/Team:HUNGENIOUS/Summary">Summary</a></li> |
| <li><a href="https://2014hs.igem.org/Team:HUNGENIOUS/Article">Article</a></li> | | <li><a href="https://2014hs.igem.org/Team:HUNGENIOUS/Article">Article</a></li> |
| + | <li><a href="https://2014hs.igem.org/Team:HUNGENIOUS/Sources">Sources</a></li> |
| </ul> | | </ul> |
| </li> | | </li> |
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- | <h1>Motivation</h1> | + | <h1>Introduction</h1> |
- | <p>This summer, the 2013 MIT iGEM team worked to engineer exosome mediated cell-cell communication. In vivo cell-cell communication is vital for pattern formation, organ development, coordinated responses to environmental changes, and the maintenance of an organism (Bacchus, 2012)</p> | + | <p>We are a marvelous appletree of superheroe-apples from Szeged.</p> |
- | <h1>Our Contribution</h1> | + | <iframe width="760" height="480" src="//www.youtube.com/embed/Co95-XJddh8" frameborder="0" allowfullscreen></iframe> |
- | <p>We demonstrated that exosomes can be engineered to transport protein and miRNA signals of interest. These signals remain functional and can actuate a response in a receiver cell. By co-culturing sender and receiver cells, we have demonstrated exosome mediated unidirectional cell-cell communication. </p>
| + | |
- | <h1>Our Vision</h1>
| + | |
- | <p> Exosomes provide an innovative means of engineering cell-cell communication that can have exciting application in drug testing and development. Tissue engineers are currently working to develop organoids small tissue structures that recapitulate the behavior of organs in vitro (Lancaster, 2013). Organoids can be used to test drugs more rigorously in a human-like context rather than relying solely on animal models. Thus drugs can be developed with a better understanding of their toxicity and efficacy. These multicellular structures require cell-cell communication, and our exosome mediated communication system could serve as an enabling technology for organoid development<p>
| + | |
- | <p> Lancaster, Madeline et al. Cerebral organoids model human brain development and microcephaly. Nature 501, 373–379 (2013)
| + | |
- | Bacchus, William et al. Synthetic two-way communication between mammalian cells. Nat. Biotechnol. 30, 991–996 (2012)
| + | |
- | </p> | + | |
| | | |
| | | |
| <h1>Sponsors</h3> | | <h1>Sponsors</h3> |
| <ul id="leftsponsors" style="text-align:center"> | | <ul id="leftsponsors" style="text-align:center"> |
- | <li><a href="http://www.eecs.mit.edu/"><img src='https://static.igem.org/mediawiki/2011/2/22/Mit-eecs.jpg' /></a></li> | + | <li><a href="http://www.mabite.info/"><img src='http://kozepiskolas.mabite.info/images/logo_01_01.jpg' style="width:175px;"/></a></li> |
- | <li><a href="http://web.mit.edu/be/"><img src='https://static.igem.org/mediawiki/2011/a/a7/Mit-be.jpg' /></a></li>
| + | |
- | <li><a href="http://web.mit.edu/cheme/"><img src='https://static.igem.org/mediawiki/2012/0/01/Cheme.png' style="width:175px"></a></li>
| + | |
- | <li><a href="https://2012.igem.org/Main_Page"><img src='https://static.igem.org/mediawiki/igem.org/d/de/IGEM_basic_Logo_stylized.png' style="width:175px;"></a></li> | + | |
| </ul> | | </ul> |
| | | |
| <ul id="centersponsors" style="text-align:center"> | | <ul id="centersponsors" style="text-align:center"> |
- | <li><a href="http://www.geneious.com"><img src='https://static.igem.org/mediawiki/2011/6/65/Mit-geneious.jpg' /></a></li> | + | <li><a href="http://www.szbk.u-szeged.hu/index.php"><img src='http://www.mmpharma.com/images/logos/brclogo.gif' style="width:175px;"></a></li> |
- | <li><a href="http://www.genewiz.com"><img src='https://static.igem.org/mediawiki/2011/3/33/Mit-genewiz.jpg' /></a></li>
| + | <li><a href="https://2014hs.igem.org/Main_Page"><img src='https://static.igem.org/mediawiki/igem.org/d/de/IGEM_basic_Logo_stylized.png' style="width:175px;"></a></li> |
- | <li><a href="http://www.addgene.org/"><img src='https://static.igem.org/mediawiki/2012/5/58/Addgene.png' /></a></li> | + | <li><a href="http://www.maviz.org/tmv_tisza_maros_vizikozmu_uzemelteto_kft"><img src='https://static.igem.org/mediawiki/2014hs/e/ea/Vizmu2.png' style="width:175px;"></a></li> |
- | <li><a href="http://www.ll.mit.edu/"><img width="100%" src='https://static.igem.org/mediawiki/2013/6/6b/LL_Logo_blue.jpg' /></a></li>
| + | |
- | <li><a href="http://www.qiagen.com/"><img width="70%" src='https://static.igem.org/mediawiki/2013/0/0c/Qiagen-logo.GIF' /></a></li> | + | |
- | <li><a href="http://gen9bio.com/"><img width="100%" src='https://static.igem.org/mediawiki/2013/3/33/Gen9logo.png' /></a></li>
| + | |
| </ul> | | </ul> |
| | | |
| <ul id="rightsponsors" style="text-align:center"> | | <ul id="rightsponsors" style="text-align:center"> |
- | <li><a href="http://ebics.net"><img src='https://static.igem.org/mediawiki/igem.org/0/0d/EBICS_logo.JPG' style="width:175px"></a></li> | + | <li><a href="http://www.radnoti-szeged.sulinet.hu/"><img src='http://www.radnoti-szeged.sulinet.hu/media/media_5.gif' style="width:175px"></a></li> |
- | <li><a href="http://ehs.mit.edu/site/"><img src='https://static.igem.org/mediawiki/2012/5/52/Ehs_logo.jpg'></a></li>
| + | |
- | <li><a href="http://www.monsanto.com/Pages/default.aspx"><img src='https://static.igem.org/mediawiki/2012/1/18/Monsanto.png'></a></li>
| + | |
- | <li><a href="http://www.idtdna.com/site"><img src='https://static.igem.org/mediawiki/2012/4/41/Idt2.png'></a></li>
| + | |
- | <li><a href="http://www.thirdrockventures.com/"><img width="100%" src='https://static.igem.org/mediawiki/2013/8/8d/Thirdrock.jpg'></a></li>
| + | |
- | <li><a href="http://www.alnylam.com/"><img width="100%" src='https://static.igem.org/mediawiki/2013/c/c8/Alnylam-Pharmaceuticals-Inc-ALNY.png'></a></li>
| + | |
| </ul> | | </ul> |
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