Team:TP CC-SanDiego/Members

From 2014hs.igem.org

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<h2>Anisa Malangone</h2>
<h2>Anisa Malangone</h2>
<h3>Junior at Torrey Pines High School</h3>
<h3>Junior at Torrey Pines High School</h3>
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              <h3>Why I'm Doing iGEM: I love learning, especially about science, and have had
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some great experience in a lab at UCSD with neuroscience, but I was also drawn
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to synthetic biology and iGEM was the perfect way to learn more.</h3><h3>Coolest thing about science: How much is unknown, and changing and yet to
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be discovered as well as how different areas of science link together.</h3><h3>Hobby: watching movies like UP, reading things by C.S. Lewis, playing word
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games like hink pink, collecting quotes with my best friend, going on adventures
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to different counties, listening to Simon and Garfunkel, hiking at Torrey Pines
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reserve, having long talks, and of course synthetic biology</h3><h3>Career plans: MD (neurosurgeon) & or PhD (focusing on either neuroscience or
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bioengineering)</h3>
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Revision as of 01:15, 16 April 2014

{ iGEM San Diego

STATISTICS
Statistics that are quite relevant to the nature of this experiment

Toxicity of aflatoxin is 10 times that of hydrocyanic acid and 68 times of arsenic.

This disease is the third-leading cause of cancer death globally according to WHO (2008), with about 550,000–600,000 new cases each year.

This disease is the third-leading cause of cancer death globally according to WHO (2008), with about 550,000–600,000 new cases each year
ENGINEERING
E. Coli Capable of Extracelluar Secretion of Mycotoxin Detoxifying Enzymes
Microfungi that produce harmful mycotoxins flourish on improperly-stored nuts, grains, meat, and dairy. They especially thrive in developing countries, where the lack of advanced food storage and mycotoxin exposure causes 40% of the diseases. To lessen the problem, our team engineered E. coli strains using synthetic biology tools to produce chimeric mycotoxin-degrading fungal enzymes, Aflatoxin-Detoxifizyme (ADTZ) and Zearalenone Hydrolase (ZHD101), which are designed to be secreted to extra-cellular space by fusing with secretion signal peptides from alpha-amylase and beta-lactamase. In this study, we have successfully generated synthetic genetic materials to produce four chimeric mycotoxin-detoxifying enzymes. The levels of extracellular secretion is also characterized and analyzed. The project will allow a mass production of detoxification enzymes in cost effective way, preventing the squandering of harvested crops, and limiting mycotoxin-related diseases. Increased access to these proteins will have an immense commercial, industrial, agricultural, and health impact.

Team Members

Brandon Read

Senior at Torrey Pines High School

Michael Margolis

Junior at Torrey Pines High School

Gha Young Lee

Junior at Torrey Pines High School

Mokhshan Ramachandran

Senior at Torrey Pines High School

Brian Choi

Senior at Torrey Pines High School

Hobby: Singing like Kurt Hummel from Glee and watching Big Bang Theory

What I want to major in college: Aerospace Engineering

Future job: Husband

Abilities: singing in high pitch, eating 210 pieces of hot cheetos per day, knitting, passive aggression

Interesting facts: I was casted in The Light in the Piazza as Giuseppe Naccarelli.

Favorite Quote: "Hard work beats talent when talent does not work hard."

Anisa Malangone

Junior at Torrey Pines High School

Why I'm Doing iGEM: I love learning, especially about science, and have had some great experience in a lab at UCSD with neuroscience, but I was also drawn to synthetic biology and iGEM was the perfect way to learn more.

Coolest thing about science: How much is unknown, and changing and yet to be discovered as well as how different areas of science link together.

Hobby: watching movies like UP, reading things by C.S. Lewis, playing word games like hink pink, collecting quotes with my best friend, going on adventures to different counties, listening to Simon and Garfunkel, hiking at Torrey Pines reserve, having long talks, and of course synthetic biology

Career plans: MD (neurosurgeon) & or PhD (focusing on either neuroscience or bioengineering)

Melinda Wang

Junior at Torrey Pines High School

Victoria Ouyang

Junior at Torrey Pines High School

Christina Baek

Sophomore at Torrey Pines High School

Evan Kallenberg

Senior at Torrey Pines High School

Ellen Ouyang

Sophomore at Canyon Crest Academy

Daniel Sands

Junior at Canyon Crest Academy

Aidan Kahng

Sophomore at Torrey Pines High School

Zilu Pan

Sophomore at Canyon Crest Academy

Nikki Nikkhoy

Junior at Torrey Pines High School

Alexander Wen

Freshman at Torrey Pines High School

Julia Wisnia

Freshman at Canyon Crest Academy