Team:TP CC-SanDiego/Members

From 2014hs.igem.org

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<h2>Dr. Mayi Arcellana-Panlilio</h2>
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<h3>Biochemistry &#38; Molecular Biology (Professor)</h3>
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<p>I have been involved with teaching/mentoring in the Bachelor of Health Sciences program since 2003, primarily to develop and deliver the Honours Cell & Molecular Biology course, a core requirement in the curriculum. I have taught every offering of that course and received numerous accolades from the Faculty and the students, most recently winning the Teaching Excellence Award for 2010-2011 from the University of Calgary Students Union. This is my third year as an iGEM Instructor and my interest in the program springs from my belief in the value of inquiry as a means to getting students engaged in the pursuit of knowledge and developing habits of becoming lifelong learners.</p>
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<h3><a href="http://www.linkedin.com/pub/mayi-arcellana-panlilio/1/649/b25" target="_blank">View My LinkedIn Profile</a></h3>
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<h2>Dr. Mark Bieda</h2>
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<p>My overall research areas are in bioinformatics and epigenetics. I’m particularly interested in roles of epigenetic modifications in controlling processes in neuroscience and cancer. Here, I use epigenetics in the “modern” sense (some would say incorrect sense) to refer to modifications of DNA and histones to control gene expression. I’d add in transcription factors here, too, with the risk of diluting epigenetic to just mean “transcriptional regulation”.</p>
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<h2>Dr. Anthony Schryvers</h2>
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<h3>Microbiology, Immunology, &#38; Infectious Diseases (Professor)</h3>
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<p>I obtained a PhD in Biochemistry at the University of Alberta and an MD at the University of Calgary. During my Postdoctoral training at U of C I also served a 2 1/2 year term as VP Research for Chembiomed.  During my first 17 years as a faculty member at the University of Calgary I was focused primarily on research. I have been involved in the Bachelor of Health Sciences program since its inception, and currently serve as Director of the Program and as Associate Dean, Undergraduate Science Education. I currently hold appointments in the Departments of Microbiology, Immunology & Infectious Diseases and Biochemistry & Molecular Biology in the Faculty of Medicine, and in the Department of Food Production Animal Health in the Faculty of Veterinary Medicine.</p>
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<h2>Dr. Cesar Rodriguez</h2>
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<h3>Senior Research Scientist (AutoDesk, Inc.)</h3>
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<p>I am a Senior Research Scientist in the Bio/Nano/Programmable Matter group at Autodesk where I focus on computer-aided design of biological systems. Prior to joining Autodesk, I was the Synthetic Biology Research Lead at Genome Compiler and Software Lead at BIOFAB: International Open Facility Advancing Biotechnology (BIOFAB). I am a co-founder and former co-editor of the Synthetic Biology Open Language (SBOL), an emerging data exchange standard and have been an iGEM judge the last four years. Beyond pursuing exciting ideas and projects in Synthetic Biology, I enjoy raising two rambunctious daughters, snowboarding, football, computer animation (especially Pixar), electric cars, and travelling.</p>
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<h3><a href="http://www.linkedin.com/pub/cesar-rodriguez/b/430/a64" target="_blank">View My LinkedIn Profile</a></h3>
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<h2>Justin Dole</h2>
<h2>Justin Dole</h2>

Revision as of 23:07, 9 March 2014

{ iGEM San Diego

STATISTICS
Statistics that are quite relevant to the nature of this experiment

Toxicity of aflatoxin is 10 times that of hydrocyanic acid and 68 times of arsenic.

This disease is the third-leading cause of cancer death globally according to WHO (2008), with about 550,000–600,000 new cases each year.

This disease is the third-leading cause of cancer death globally according to WHO (2008), with about 550,000–600,000 new cases each year
ENGINEERING
E. Coli Capable of Extracelluar Secretion of Mycotoxin Detoxifying Enzymes
Microfungi that produce harmful mycotoxins flourish on improperly-stored nuts, grains, meat, and dairy. They especially thrive in developing countries, where the lack of advanced food storage and mycotoxin exposure causes 40% of the diseases. To lessen the problem, our team engineered E. coli strains using synthetic biology tools to produce chimeric mycotoxin-degrading fungal enzymes, Aflatoxin-Detoxifizyme (ADTZ) and Zearalenone Hydrolase (ZHD101), which are designed to be secreted to extra-cellular space by fusing with secretion signal peptides from alpha-amylase and beta-lactamase. In this study, we have successfully generated synthetic genetic materials to produce four chimeric mycotoxin-detoxifying enzymes. The levels of extracellular secretion is also characterized and analyzed. The project will allow a mass production of detoxification enzymes in cost effective way, preventing the squandering of harvested crops, and limiting mycotoxin-related diseases. Increased access to these proteins will have an immense commercial, industrial, agricultural, and health impact.

Team Members

Brandon Read

Senior at Torrey Pines High School

Gha Young Lee

Junior at Torrey Pines High School

Michael Margolis

Junior at Torrey Pines High School

Mokhshan Ramachandran

Senior at Torrey Pines High School

Brian Choi

Senior at Torrey Pines High School

Justin Dole

Biological Sciences (2nd Year)

Heading into my second undergraduate year, I can undoubtedly say that the past few months have helped put my academic knowledge into context. I held various roles this summer, but was ultimately in charge of qualitative modelling using Autodesk Maya. This has been my first year with iGEM; the exposure to various disciplines has allowed me to see the interconnectivity between synthetic biology, engineering, and business. Besides waiting for the lab computer to process 22GB of RAM, I take pride in eating well, exercising regularly, sleeping in, and picking flowers for my Mom. I two-strap my backpack, have a keen interest in entrepreneurship, technology, and medicine, and love anything with an engine to the point that I consider myself obsessed.

Su Wang

Chemical Engineering (4th Year)

I am a chemical engineering student with a specialization in biomedical engineering. Prior to join iGEM I have been doing researches in chemical engineering labs for thermodynamics or in-situ oil upgrading. Those were professor-driven research projects where even though I had good experiences, there was little I could do to test my own hypothesis. That's why I came for iGEM; for the student driven research aspect. Here I wish to combine with what I have learned from system biology class, with my training in modelling, to work on things that interest me!

Sharon Feng

Biomedical Sciences (3rd Year)

This summer was my first year being involved in iGEM and a wet lab setting. I was fortunate to be a member of the TALEs team where I have learned so much about synthetic biology, bacterial genetics, and general lab practices. Last year, I was involved with clinical studies of children with inflammatory bowel disease at the Alberta Children's Hospital. In my free time, I enjoy reading novels, watching movies, and spending time with family and friends.

Amanda Zucoloto

Biomedical Sciences (3rd Year)

This is my first year on iGEM and I have been working with TALEs, which involved alternative cloning strategies and lots of fun time doing protein work over the Summer. When I am not pippeting in the lab to the sound of Backstreet Boys, I spend my time working out, exploring Canada and catching up with family and friends who are all the way back in Brazil. Even though I still have a couple months here in Calgary, I can't wait to come back as a graduate student!

Julie Osgood

Biomedical Sciences (3rd Year)

This is my first year with iGEM and I have spent my summer focusing on the TALE aspect of our project. I devoted my time to designing the E. coli target sequences and putting together our TALE constructs. When I’m not redoing all my experiments that didn’t work, I enjoy dancing, reading, and watching Battestar Galactica. I have spent my past couple summers working in research labs, but I loved having the opportunity to join a student driven research team. In the future I hope to be a professional Quidditch player or a geneticist.

Ali Honarmand

Biological Sciences (4th Year)

This is my 2nd year of iGEM and I am leading the TALEs part of the project. That is how I got nicknamed "TALI.". I really like how iGEM is completely student driven and how it is not just about the science. It has really broadened my perspectives about all the different components that need to go into a project to make it successful and useful to the society. When I'm not in the lab serving dinner to E. coli or sitting in front of my computer staring at ATCGs, you can find me appreciating the gravity in the mountains either on my bike or snowboard, reading a book, or trying something completely random.

View My LinkedIn Profile

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