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Team:HUNGENIOUS
From 2014hs.igem.org
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The Crohn's disease is a chronical, festering, intestinal disease. The whole intesine is sappurated, it's incurable. Our aim with the second project is protection in simple and cheap way with N-acetylglucosamine. Animal cells doesn't have a periplast, only an extracellular matrix surrounds the cells in order to protect them. The N-acetylglucosamine connects to this matrix increasing its protective effect. As the N-acetylglucosamine's polymer form is the chitin, therefore we can produce chitinase enzyme with a bacterium which is also an intestinal one which can disassemble the chitin to N-acetylglucosamine. | The Crohn's disease is a chronical, festering, intestinal disease. The whole intesine is sappurated, it's incurable. Our aim with the second project is protection in simple and cheap way with N-acetylglucosamine. Animal cells doesn't have a periplast, only an extracellular matrix surrounds the cells in order to protect them. The N-acetylglucosamine connects to this matrix increasing its protective effect. As the N-acetylglucosamine's polymer form is the chitin, therefore we can produce chitinase enzyme with a bacterium which is also an intestinal one which can disassemble the chitin to N-acetylglucosamine. | ||
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| + | Nowadays, death cap (Amanita phalloides) is one the most responsible species worldwide, which cause poisoning and significant rate of these toxications (mostly those which occur far from the necessary medical attendance) has lethal outcome. In Califonia, for example, 6300 poisonings were registered between 1993 and 1997. The main cause of these accidents is that the death cap may be confused with Agaricus species, due to their similar apperance, thus threatening verdant and negligent people. With our project it would become easier to distinguish Amanita from other species, so ensuring the mushroom we eat is not toxic. | ||
===Fun!=== | ===Fun!=== | ||
Revision as of 19:49, 7 March 2014
- a team description
- project description
- safety information (did your team take a safety training course? were you supervised in the lab?)
- team attribution (who did what part of your project?)
- lab notebook
- sponsor information
- other information
Example: 2013hs.igem.org/Team:HUNGENIOUS/Our_Pets
| You can write a background of your team here. Give us a background of your team, the members, etc. Or tell us more about something of your choosing. |  |
|
Tell us more about your project. Give us background. Use this as the abstract of your project. Be descriptive but concise (1-2 paragraphs) | File:HUNGENIOUS team.png Your team picture |
| Team HUNGENIOUS |
| Official Team Profile |
|---|
Contents |
Team
Our team is from the hungarian Radnóti Miklós High School, and it is made up of seven students from a biology class and one who comes from a maths class. We have interest in Molecular Biology. The team consist of sixteen and seventeen years old students in their 10th and 11th years of a state school. We will cooperate with the Biological Research Centre of Hungarian Academy of Sciences.
Project
We decided to start two projects. One of them is the Amanitin-biosensor. Our aim is to detect the toxin of the poisonous death cap. The other one is a bacterium which produces chitinase enzyme to treat Crohn's disease.
Notebook
We have weekly sessions on tuesdays where we discuss what we have done so far, and what to do afterwards. Every member of the team gets new tasks to do until the next meeting. We have lessons in the mornings during the weekdays, so we can only work on our project in the afternoons and on weekends.
Results/Conclusions
What did you achieve over the course of your semester?
Safety
What safety precautions did your team take? Did you take a safety training course? Were you supervised at all times in the lab?
Attributions
We have split into two groups. One is working on the Amanitin-biosensor, the other one is doing research on Crohn's disease. Our specialists on the disease are: Petra, Réka, Andris and Martin. The subteam making the biosensor consists of Miklós, Gergő, Márk and Ákos. The leader of the team is our teacher, Mr Sándor Bán.
Human Practices
The Crohn's disease is a chronical, festering, intestinal disease. The whole intesine is sappurated, it's incurable. Our aim with the second project is protection in simple and cheap way with N-acetylglucosamine. Animal cells doesn't have a periplast, only an extracellular matrix surrounds the cells in order to protect them. The N-acetylglucosamine connects to this matrix increasing its protective effect. As the N-acetylglucosamine's polymer form is the chitin, therefore we can produce chitinase enzyme with a bacterium which is also an intestinal one which can disassemble the chitin to N-acetylglucosamine.
Nowadays, death cap (Amanita phalloides) is one the most responsible species worldwide, which cause poisoning and significant rate of these toxications (mostly those which occur far from the necessary medical attendance) has lethal outcome. In Califonia, for example, 6300 poisonings were registered between 1993 and 1997. The main cause of these accidents is that the death cap may be confused with Agaricus species, due to their similar apperance, thus threatening verdant and negligent people. With our project it would become easier to distinguish Amanita from other species, so ensuring the mushroom we eat is not toxic.
Fun!
What was your favorite team snack?? Have a picture of your team mascot?
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