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Team:Elan Vital South Korea/p background
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<h1 class="title">Project Background</h1> | <h1 class="title">Project Background</h1> | ||
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| + | <p class="paragraph">MRSA is a strain of the bacterium Staphylococcus aureus, and is very dangerous, shows resistance to drugs, and can even cause serious, life-threatening problems. MRSA stands for Methicillin resistant Staphylococcus aureus. We differentiate between MRSA and non-MRSA S. aureus (or MSSA: Methicillin sensitive S. aureus) by the resistance to methicillin, but methicillin resistance is not the most important thing about MRSA. What really makes MRSA stand out from other S. aureus is that they exhibit resistance to β-lactam antibiotics. MRSA is called ‘methicillin resistant’ because methicillin is a β-lactam antibiotic, and is used commonly for finding MRSA. Because of its multidrug resistance due to evolution, MRSA is a serious problem in the medical community. MSSA, the strain of staphylococcus that is sensitive to β-lactam antibiotics, was not considered a serious threat, but in the last 50 years, mutations led to MRSA, which was much more dangerous than the original staphylococcus aureus. Originally, staphylococcus aureus was not contagious, but MRSA is very contagious with high frequencies of nosocomial infections.</p> | ||
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<p class="paragraph">MRSA is an acronym for the pathogen Staphylococcus aureus. MRSA developed resistance to β-lactam antibiotics in a large extent. Currently the methicillin resistance has been widely used as an indication for the β-lactam resistant phenotype of this pathogen. | <p class="paragraph">MRSA is an acronym for the pathogen Staphylococcus aureus. MRSA developed resistance to β-lactam antibiotics in a large extent. Currently the methicillin resistance has been widely used as an indication for the β-lactam resistant phenotype of this pathogen. | ||
As a micro-organism in Staphylococcus genus, which are Gram-positive cocci, MRSA is usually found in a skin colonized by bacteria and in nasal passages of many healthy people. They stay as carriage state in healthy people’s skin flora, and there are two predominant species: Staphylococcus epidermidis and S. aureus, which refers to the major pathogens among the staphylococci.</p> | As a micro-organism in Staphylococcus genus, which are Gram-positive cocci, MRSA is usually found in a skin colonized by bacteria and in nasal passages of many healthy people. They stay as carriage state in healthy people’s skin flora, and there are two predominant species: Staphylococcus epidermidis and S. aureus, which refers to the major pathogens among the staphylococci.</p> | ||
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<p class="paragraph">This development, however, lead to another consequence: MRSA showed an increase in vancomycin resistance, especially in the enterococci and eventually in staphylococci. Hence the science had to question whether they should use the ‘right’ agent such as vancomycin, or not to use to prevent the collateral damage resistance. </p> | <p class="paragraph">This development, however, lead to another consequence: MRSA showed an increase in vancomycin resistance, especially in the enterococci and eventually in staphylococci. Hence the science had to question whether they should use the ‘right’ agent such as vancomycin, or not to use to prevent the collateral damage resistance. </p> | ||
<p class="paragraph">Current empirical antibiotic hospital treatment options for MRSA are vancomycin, linezolid, quinupristin, dalfospristin, daptomycin; but there is limit in the use of these antibiotics.</p> | <p class="paragraph">Current empirical antibiotic hospital treatment options for MRSA are vancomycin, linezolid, quinupristin, dalfospristin, daptomycin; but there is limit in the use of these antibiotics.</p> | ||
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Revision as of 13:20, 14 June 2014
Project Background
MRSA is a strain of the bacterium Staphylococcus aureus, and is very dangerous, shows resistance to drugs, and can even cause serious, life-threatening problems. MRSA stands for Methicillin resistant Staphylococcus aureus. We differentiate between MRSA and non-MRSA S. aureus (or MSSA: Methicillin sensitive S. aureus) by the resistance to methicillin, but methicillin resistance is not the most important thing about MRSA. What really makes MRSA stand out from other S. aureus is that they exhibit resistance to β-lactam antibiotics. MRSA is called ‘methicillin resistant’ because methicillin is a β-lactam antibiotic, and is used commonly for finding MRSA. Because of its multidrug resistance due to evolution, MRSA is a serious problem in the medical community. MSSA, the strain of staphylococcus that is sensitive to β-lactam antibiotics, was not considered a serious threat, but in the last 50 years, mutations led to MRSA, which was much more dangerous than the original staphylococcus aureus. Originally, staphylococcus aureus was not contagious, but MRSA is very contagious with high frequencies of nosocomial infections.
