Team:TP CC-SanDiego/School

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iGEM San Diego

STATISTICS
Statistics that are quite relevant to the nature of this experiment

Toxicity of aflatoxin is 10 times that of hydrocyanic acid and 68 times of arsenic.

This disease is the third-leading cause of cancer death globally according to WHO (2008), with about 550,000–600,000 new cases each year.

This disease is the third-leading cause of cancer death globally according to WHO (2008), with about 550,000–600,000 new cases each year
ENGINEERING
E. Coli Capable of Extracelluar Secretion of Mycotoxin Detoxifying Enzymes
Microfungi that produce harmful mycotoxins flourish on improperly-stored nuts, grains, meat, and dairy. They especially thrive in developing countries, where the lack of advanced food storage and mycotoxin exposure causes 40% of the diseases. To lessen the problem, our team engineered E. coli strains using synthetic biology tools to produce chimeric mycotoxin-degrading fungal enzymes, Aflatoxin-Detoxifizyme (ADTZ) and Zearalenone Hydrolase (ZHD101), which are designed to be secreted to extra-cellular space by fusing with secretion signal peptides from alpha-amylase and beta-lactamase. In this study, we have successfully generated synthetic genetic materials to produce four chimeric mycotoxin-detoxifying enzymes. The levels of extracellular secretion is also characterized and analyzed. The project will allow a mass production of detoxification enzymes in cost effective way, preventing the squandering of harvested crops, and limiting mycotoxin-related diseases. Increased access to these proteins will have an immense commercial, industrial, agricultural, and health impact.

Our School

Torrey Pines High School

Torrey Pines High School is a member of the San Dieguito Union High School District and is located in the North County Coastal area of San Diego. The school opened in 1974 and is a three time National Blue Ribbon School as well as a California Distinguished School. In the 1980s, Torrey Pines High School was expanded, creating more classrooms; a new parking lot; a football stadium; and a new black box theater. In 2003, there was the addition of Building E and G. Torrey Pines High School has a primarily Asian, Caucasian, and Hispanic student body - whom reflect the affluent surrounding area. The neighboring institutions such as the University of California, San diego, Scripps Institute of Oceanography, the Salk Institute, the Scripps Clinic and Research Foundation, and the Burnham Institute all influence the high school’s high standard of education and expectation. Torrey Pines High School is headed by its principal, David Jaffe, who arrived at the school in the 2013-2014 school year. The school’s vision is to be a dynamic community of lifelong learners who make significant contributions in our world and strive to facilitate student growth so that they become self-directed learners, effective communicators, collaborative workers, quality producers, and global citizens who actively participate in their community.

Canyon Crest Academy

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