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Team:Lethbridge Canada
From 2014hs.igem.org
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===Project=== | ===Project=== | ||
| - | + | On average, skin requires 2-6 weeks for full regeneration depending on the severity of the injury. For major burns, skin grafts are required to create the scaffolding for the skin cells to duplicate and create a bridge to seal the wound. According to the American Burn Association in 2002, 1.1 million burn injuries require medical attention. Additionally, in a report by Brown University, the cost to treat a serious burn without surgery is $9 000, and $30,000 on average with surgery. Research is currently being conducted on producing artificial skin to reduce needed surgeries to extract skin from a patient’s body, healing time, and cost. These methods however, such as the use of mesenchymal stem cells (MSCs)-adult human stem cells to produce the needed scaffolding to create the graft, are invasive. | |
| + | Type I collagen is the most abundant form of collagen in the body. During the formation of collagen in human cells, alpha-1 and alpha-2 helices are formed during translation to form peptide chains. Our goal is to synthesize a collagen matrix using an organism in the lab by encoding this process into its genetic makeup. Utilizing collagen to assist in the natural healing process would enable patients with wounds of varying severity to heal faster. In addition, the increased speed of healing would reduce the chance of infection as the wound will close and begin to repair in a shorter time. Furthermore, collagen would be especially useful in diabetic patients as their wounds heal slowly relative to non-diabetic individuals. Ultimately, we hope our project will create opportunities in the medical field for further testing to create a cheaper, non-invasive and more viable source for faster skin regeneration. | ||
===Notebook=== | ===Notebook=== | ||
Revision as of 22:55, 7 March 2014
- a team description
- project description
- safety information (did your team take a safety training course? were you supervised in the lab?)
- team attribution (who did what part of your project?)
- lab notebook
- sponsor information
- other information
Example: 2013hs.igem.org/Team:Lethbridge_Canada/Our_Pets
| You can write a background of your team here. Give us a background of your team, the members, etc. Or tell us more about something of your choosing. | |
|
Tell us more about your project. Give us background. Use this as the abstract of your project. Be descriptive but concise (1-2 paragraphs) | File:Lethbridge Canada team.png Your team picture |
| Team Lethbridge_Canada |
| Official Team Profile |
|---|
Contents |
Team
Tell us about your team, your school!
Project
On average, skin requires 2-6 weeks for full regeneration depending on the severity of the injury. For major burns, skin grafts are required to create the scaffolding for the skin cells to duplicate and create a bridge to seal the wound. According to the American Burn Association in 2002, 1.1 million burn injuries require medical attention. Additionally, in a report by Brown University, the cost to treat a serious burn without surgery is $9 000, and $30,000 on average with surgery. Research is currently being conducted on producing artificial skin to reduce needed surgeries to extract skin from a patient’s body, healing time, and cost. These methods however, such as the use of mesenchymal stem cells (MSCs)-adult human stem cells to produce the needed scaffolding to create the graft, are invasive.
Type I collagen is the most abundant form of collagen in the body. During the formation of collagen in human cells, alpha-1 and alpha-2 helices are formed during translation to form peptide chains. Our goal is to synthesize a collagen matrix using an organism in the lab by encoding this process into its genetic makeup. Utilizing collagen to assist in the natural healing process would enable patients with wounds of varying severity to heal faster. In addition, the increased speed of healing would reduce the chance of infection as the wound will close and begin to repair in a shorter time. Furthermore, collagen would be especially useful in diabetic patients as their wounds heal slowly relative to non-diabetic individuals. Ultimately, we hope our project will create opportunities in the medical field for further testing to create a cheaper, non-invasive and more viable source for faster skin regeneration.
Notebook
Show us how you spent your days.
Results/Conclusions
What did you achieve over the course of your semester?
Safety
What safety precautions did your team take? Did you take a safety training course? Were you supervised at all times in the lab?
Attributions
Who worked on what?
Human Practices
What impact does/will your project have on the public?
Fun!
What was your favorite team snack?? Have a picture of your team mascot?
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