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-	<title>Project Overview - TAS Taipei iGEM Wiki</title>
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-					<a href="https://2014hs.igem.org/Team:TAS_Taipei" style='text-decoration: none'><img src="https://static.igem.org/mediawiki/2014hs/2/2f/Tas_igemlogo.png
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-					<a href="https://2014hs.igem.org/Team:TAS_Taipei" style='text-decoration: none'>
-						<h2 style="font-family:Railway;letter-spacing:10px;color: white;  font-size: 65px;  margin-top: 0;  margin-bottom: 0;">E-MORTALITY</h2>
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-				<a href="https://2014hs.igem.org/Team:TAS_Taipei/project/overview"><h4 class="dropdown-toggle disabled" data-toggle="dropdown">PROJECT</h4></a>
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-						<img src="https://static.igem.org/mediawiki/2014hs/2/23/Project_icon.PNG">
-						<h4>Telomere extension.  Prolongation of cell life.  Explore our three component system that not only extends telomeres, but regulates the length and ensures safety.</h4>
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-							<h5><a href="https://2014hs.igem.org/Team:TAS_Taipei/project/abstract">Background</a></h5>
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-							<h5><a href="https://2014hs.igem.org/Team:TAS_Taipei/project/telomere_extension">Telomere Extension</a></h5></div>
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-							<h5><a href="https://2014hs.igem.org/Team:TAS_Taipei/project/circuit_regulation">Circuit Regulation</a></h5>
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-							<h5><a href="https://2014hs.igem.org/Team:TAS_Taipei/project/safety_switch">Safety Switch</a></h5>
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-							<h5><a href="https://2014hs.igem.org/Team:TAS_Taipei/project/parts_submissions">Parts Submissions</a></h5>
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-				<a href="https://2014hs.igem.org/Team:TAS_Taipei/modeling/overview"><h4 class='dropdown-toggle disabled' data-toggle="dropdown">MODELING</h4></a>
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-						<img src="https://static.igem.org/mediawiki/2014hs/f/f0/Experiments_icon.png">
-						<h4>Computational biology is becoming more reliable as a predictor of experimental data.  Click to see how modeling helped us decide what experimental steps to take.</h4>
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-							<h5><a href="https://2014hs.igem.org/Team:TAS_Taipei/modeling#telomere_extension">Telomere Extension</a></h5>
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-							<h5><a href="https://2014hs.igem.org/Team:TAS_Taipei/modeling#circuit_regulation">Circuit Regulation</a></h5>
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-				<a href="https://2014hs.igem.org/Team:TAS_Taipei/human_practice/overview"><h4 class='dropdown-toggle disabled' data-toggle="dropdown">HUMAN PRACTICE</h4></a>
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-						<img src="https://static.igem.org/mediawiki/2014hs/8/8d/Human_practice_icon.png">
-						<h4>Take a look at the research and outreach that shaped our entire E.Mortality project.</h4>
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-							<h5><a href="https://2014hs.igem.org/Team:TAS_Taipei/human_practice#research">Research</a></h5>
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-						<h4>Lab safety is of utmost importance.  Here are the precautions we've taken to maximize our lab safety.</h4>
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-						<h4>Want to know more about us?  Sneak-a-peek and read about our interests and learn about where we are from.</h4>
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-							<h5><a href="https://2014hs.igem.org/Team:TAS_Taipei/team#members">Members</a></h5>
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-							<h5><a href="https://2014hs.igem.org/Team:TAS_Taipei/team#about">About</a></h5>
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-							<h5><a href="https://2014hs.igem.org/Team:TAS_Taipei/attributions">Attributions</a></h5>
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-						<h4>Organization is key.  Our calendar and wet-lab notebook are located here.</h4>
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-							<h5><a href="https://2014hs.igem.org/Team:TAS_Taipei/notebook#experiments">Experiments</a></h5>
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-							<h1 class='overview_header'>Project Overview</h1>
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-							<img src="https://static.igem.org/mediawiki/2014hs/1/1f/Background_%28for_extension%29.png" style='float:right;width:200px;border-radius:10px;'>
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-							<p>Telomeres are repeating sequences of TTAGGG nucleotides at the ends of somatic cell chromosomes. These sequences protect cellular genomes from harmful effects associated with chromosome shortening during cell replication. Due to the finite length of telomeres, telomere shortening is known to be a primary contributor to cellular senescence and cell death. To allow human somatic cells to replicate indefinitely, we have engineered a biological circuit with three primary components to regulate telomere length. (1) Expression of the reverse transcriptase enzyme telomerase to extend telomeres (2) Regulation of the amount of telomerase expressed using an oscillatory mechanism (3) Operation of a safety device to prevent possible cancerogenesis. Through the cooperation of these three mechanisms, and the tools of synthetic biology, lifespan extension is possible.</p>
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-							<h3>Extension</h3>
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-							<h2>Background</h2>
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-							<h3>&nbsp;</h3>
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-							<h2>Telomere Extension</h2>
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-							<h3>Regulation</h3>
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-							<h2>Background</h2>
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-							<h3>&nbsp;</h3>
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-							<h2>3 Component Repressilator</h2>
-							<p>This oscillator would express c-Myc in doses, as it does the repressor proteins, through a series of promoter inductions and repressions. </p>
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-							<h3>&nbsp;</h3>
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-							<h2>2 Component Oscillator</h2>
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-							<h3>Termination</h3>
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-							<h3>&nbsp;</h3>
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Team:TAS Taipei/project/overview

From 2014hs.igem.org

Latest revision as of 03:43, 21 June 2014