Team:Shenzhen SFLS

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Revision as of 09:15, 8 May 2014

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	Team Shenzhen_SFLS

Team description for Shenzhen_SFLS

Shenzhen_SFLS is an energetic iGEM high school team which represents Shenzhen Foreign Languages High School [1], located in Shenzhen, China.

Shenzhen&Shenzhen Foreign Languages School

Shenzhen is a beautiful seaside city located in southern China, which is next to Hong Kong. Within thirty years Shenzhen has developed from a fishing village to a world class city. It’s a young city, but has endless energy and potential.

Shenzhen Foreign Languages School is one of the best high schools in Shenzhen. Our school lies in Yantian District beside the Wutong Mountain, the highest peak in Shenzhen. Every morning we open our eyes, breathe in the fresh air and start a good day. SFLS is the acronym of our school name. It is a part of our team name because we love SFLS. We are proud to be SFLSers!

BGI

(to be continued)

Members

Our team includes 19 students, 3 instructors and 1 advisor. Our school collaborated with BGI Shenzhen to take part in iGEM High School Season. Team members have different personalities, but we are able to cooperate with each other in order to achieve every goal we’ve set.

Students

● 2013 Team members: Hekang JIA, Biwei ZHENG, Ruping LIU

● Captain: Yuying ZHANG (e-mail address:zyy981001@hotmail.com) – blablabla ● Vice Captain: Xin JIANG ● Directors of Theory:

      ○Wenxiu YE
      ○Jieying YE

● Director for Experiment: Zhengfeng LIU ● Director for Modeling: Jiayan GUO ● Director for Human Practice: Xiangyu LIANG ● Other members: Junwei MA, Xinru LIU, Zhiran XU, Tiantian WEI, Ziwei XU, Xueying XIANG, Yue DENG, Xinqi LV, Shuheng HU

Instructors

The following teachers closely collaborated with our team. ● Boxiang WANG ● Juan DENG ● Peilin LI

Advisor

● Shuang ZHU

Synthetic biology brings us all together despite our varied personalities. Our hearts gather together, seeking for knowledge, love and joy.

For more information

● Shenzhen Foreign Languages School http://www.sfls.net.cn/ ● Wikipedia for Shenzhen Foreign Languages School http://zh.wikipedia.org/wiki/%E6%B7%B1%E5%9C%B3%E5%A4%96%E5%9C%8B%E8%AA%9E%E5%AD%B8%E6%A0%A1 ● BGI http://www.genomics.cn/index ● Wikipedia for BGI http://zh.wikipedia.org/wiki/%E5%8D%8E%E5%A4%A7%E5%9F%BA%E5%9B%A0

Everybody is welcome to contact us on shenzhen_sfls@hotmail.com. So let’s keep in touch!

Project

Project Description

Shenzhen_SFLS 2014 project description

To begin with

Aflatoxin B1 generated by Aspergillus flavus is a kind of lethal toxin that always contaminates the grains we eat. Aimed to minimize the harm, our project consists of 3 parts from different aspects: killing Aspergillus flavus, neutralizing aflatoxin B1, and reducing the virulence of aflatoxin B1 by turning it into weaker aflatoxin M1.

Killing Aspergillus flavus

Our engineered bacteria will increase its output of antifungal compounds (which can kill Aspergillus flavus) drastically after being inplanted the engineered circuit. Therefore, this process greatly improves the efficiency of the delimitation of Aspergillus flavus.

Neutralizing Aflatoxin B1

By optimizing the circuit, aflatoxin will be combined with certain antibodies, and further be immobilized on E.coli’s membrane protein.

Transforming toxic aflatoxin B1 into aflatoxin M1

It will produce astaxanthin to transform fatal aflatoxin B1 into less toxic aflatoxin M1 after its circuit is constructed. In this way, those toxicated grains would be detoxified and would even reach edible standard. We are now trying to improve the yield of astaxant.

In conclusion

As long as the plan is carried out smoothly, three circuits would be connected into a system. The system will start to produce antifungal compounds automatically once aflatoxin B1 is detected. At the same time, it will trigger E.coli to produce the antibody. Once the antibody is immobilized on the membrane protein, astaxanthin will start to be generated by. As a result, aflatoxin B1 is transformed into aflatoxin M1.

If our project is carried out successfully and is applied in real life, human beings would benefit from it to a great extent. In fact, aflatoxin contamination in agriculture and animal husbandry causes a loss of hundreds of million dollars per year. Despite the harsh current situation, we still believe that our relentless effort will bring the problem to an end. The contaminated grains would be detoxified until they are eligible. To be optimistic, many problems the whole population face about human health such as the storage of grains, the food's safety and medical hygiene problems would be solved by our project.

Notebook

Show us how you spent your days.

Results/Conclusions

What did you achieve over the course of your semester?

Safety

What safety precautions did your team take? Did you take a safety training course? Were you supervised at all times in the lab?

Attributions

Who worked on what?

Human Practices

What impact does/will your project have on the public?

Fun!

What was your favorite team snack?? Have a picture of your team mascot? Captain Katniss Zhang has a broadcasting-style voice!Hahahhahahahaha! Director for theory Krito has a smaaaaaaaaaaaaaart brain ! Hahahhahahahaha! Director for experiment Jeff Liu is a funny guy with Rage Comic face! Hahahhahahahaha!

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